Collagenous colitis

What is collagenous colitis?

Collagenous colitis is a non-cancerous condition caused by an increased number of immune cells within tissue lining the inside of the colon. This leads to inflammation and damage which prevents the colon from functioning normally. As a result, patients with collagenous colitis can develop watery diarrhea that can last from weeks to years. Other possible symptoms can include abdominal pain, weight loss, and fatigue.

Collagenous colitis belongs to a group of related conditions called microscopic colitis. This group includes lymphocytic colitis which shares many features with collagenous colitis.

The colon

The colon is a part of the gastrointestinal tract which also includes the mouth, esophagus, stomach, small bowel, and anus. The colon is a long hollow tube that starts at the small bowel and ends at the anal canal. The colon is divided into sections which include the cecum, ascending colon, transverse colon, descending colon, sigmoid colon, and rectum. The colon absorbs water from the food that we eat and moves waste out of the body.

The colon is made up of six layers of tissue:

  • Mucosa – The mucosa is the tissue that covers the inside surface of the colon. The mucosa is lined by specialized epithelial cells that connect to form structures called glands. Some of the cells that make up the glands produce a protein called mucin which allows material inside the colon to move smoothly. When examined under the microscope, the normal, healthy glands look like long, straight test tubes with the opening at the mucosal surface and the base normally sitting on the muscularis mucosae (see below). In the colon, these long, straight glands are called crypts. The tissue that supports and is found between the glands is called the lamina propria.
  • Muscularis mucosae – The muscularis mucosae is a thin layer of tissue made up of muscle cells. The muscularis mucosae separates the mucosa from the submucosa.
  • Submucosa – The submucosa sits directly below the mucosa. It contains many thick blood vessels that bring nutrients and lymphatic channels that remove waste.
  • Muscularis propria – The muscularis propria is a thick bundle of muscle. The contraction of the muscle that forms the muscularis propria helps to propel food through the colon.
  • Subserosal adipose tissue – This is a layer of fat that surrounds the muscularis propria. The subserosal adipose tissue is near the outside surface of the colon.
  • Serosa – The serosa is a thin layer of tissue on the outside of the colon. It covers the subserosal adipose tissue.

normal colon layers

What causes collagenous colitis?

Doctors still do not know what causes a person to develop collagenous colitis in the first place. However, one theory suggests that it may be an autoimmune condition where immune cells start to attack the cells in the colon. Another theory suggests that the condition may be a reaction to material in fecal matter.

How do pathologists make this diagnosis?

If your doctor suspects collagenous colitis based on your symptoms, they will perform a colonoscopy. A colonoscopy is a procedure where a small camera is used to see the inside of your colon. During this procedure, your doctor will take tissue samples called biopsies. Because collagenous colitis can happen in one part of the colon but not another, they will likely take multiple biopsies from the entire length of the colon. Your pathologist will then examine these biopsies under a microscope to determine whether collagenous colitis is present.

For most people with collagenous colitis, their colon will look entirely normal during the colonoscopy. That is because collagenous colitis is a ‘microscopic’ disease, and its features can only be seen when the tissue is examined under a microscope.

What does collagenous colitis look like under the microscope?

In collagenous colitis, an increased number of specialized immune cells called lymphocytes are seen within the mucosa on the inside of the colon. These lymphocytes are seen both within the glands and the lamina propria. Pathologists describe this change as intraepithelial lymphocytosis.

Collagenous Colitis

Over time, the increased lymphocytes damage the glands. This damage causes the cells to become smaller. Pathologists call this change atrophy. The smaller cells produce less mucin which prevents the colon from functioning normally.

In addition, an abnormal layer of tissue forms where the epithelial cells connect with the lamina propria. This thick layer of tissue is made up of a specialized protein called collagen (which is why the condition is called collagenous colitis) and it looks pink when examined under the microscope.

The thick collagen layer traps blood vessels and immune cells near the surface of the epithelium. The extra collagen is believed to be caused by abnormal activity of support cells called myofibroblasts. Some pathologists will perform a special stain called Masson’s trichrome to highlight the collagen band.

While collagenous colitis can cause chronic inflammation in the colon, it is not the same as inflammatory bowel disease (IBD). IBD has many features which are not seen in collagenous colitis. For example, the size and shape of the crypts are abnormal. Pathologists call this change crypt distortion. To learn more about the features seen in IBD, read our article on chronic colitis.

by Catherine Forse MD FRCPC, reviewed by our Patient Partners on December 9, 2020
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