The term suspicious for malignancy is used by pathologists to describe findings that strongly suggest cancer but lack enough clear evidence to make a definitive diagnosis. When this term appears in your pathology report, it means the pathologist sees some features of cancer in your tissue sample but needs more information or additional testing before …
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DOG1 (Discovered On GIST-1) is a protein found on the surface of certain cells. Pathologists use it as a diagnostic marker, a protein they can stain for to help identify what type of tumor they are looking at. DOG1 was first discovered in gastrointestinal stromal tumors (GISTs), which is where its name comes from, but …
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Liposarcoma is a type of cancer that develops from fat cells. It is classified as a soft tissue sarcoma, which means it arises in the connective tissues of the body. Liposarcomas are most commonly found in areas where fat is normally present, such as the abdomen or limbs. While liposarcoma is rare, it is one …
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The Arias-Stella reaction is a noncancerous change most often seen in the tissue that lines the uterus, called the endometrium, and sometimes in the fallopian tube. It develops in response to pregnancy or certain hormone medications, causing the affected cells to become larger and appear unusual under the microscope. It is named after Javier Arias-Stella, …
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STAT6 (Signal Transducer and Activator of Transcription 6) is a protein found in cells. It plays a key role in transmitting signals from outside a cell to its nucleus, where genetic material is stored. This signaling helps regulate how cells grow, divide, and respond to their environment. STAT6 is especially important in controlling immune system …
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SATB2 (Special AT-rich Sequence-Binding Protein 2) is a protein that plays an important role in controlling how specific genes are turned on and off. This protein helps cells grow and function normally by organizing the genetic information inside them. SATB2 is like a “manager”, ensuring specific genes work as needed. What types of normal cells …
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This article is designed to help you understand your pathology report for CD10 positive B cell lymphoma. Each section explains an important aspect of the diagnosis and what it means for you. What is CD10 positive B cell lymphoma? CD10 positive B cell lymphoma describes a group of immune system cancers involving B cells that …
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Primary cutaneous anaplastic large cell lymphoma is a type of cancer that develops in the skin. It belongs to a group of conditions called primary cutaneous CD30-positive T-cell lymphoproliferative disorders. A lymphoma is a cancer that arises from white blood cells, and in this disease, the cancer cells come from T cells, a type of …
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Angioimmunoblastic T-cell lymphoma (AITL) is a rare and aggressive form of lymphoma that affects the immune system. It develops from T cells, a type of white blood cell that normally helps regulate the immune response. This type of lymphoma typically begins in the lymph nodes but can also affect other parts of the body, including …
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Richter transformation (also called Richter syndrome) is a serious change that can occur in people who already have chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). These are slow-growing blood cancers that behave similarly. In Richter transformation, the original cancer suddenly becomes more aggressive, which means it grows faster, spreads more quickly, and usually …
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