pathology

Transformation zone

The transformation zone is a part of the cervix where the squamous cells that make up the ectocervix meet the glandular cells that make up the endocervix. In this area of the cervix, the glandular cells that make up the endocervix are slowly replaced by squamous cells. This process is called squamous metaplasia. As a …
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S100

S100 is the name of a family of proteins found inside certain types of cells in the body. These proteins help cells respond to changes in their environment by regulating processes like growth, movement, and communication. The name “S100” comes from the fact that the proteins are soluble in a solution made with 100% saturated …
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DIF

DIF stands for direct immunofluorescence. It is a test that pathologists perform to look for specific proteins in a tissue sample. Unlike most tissue samples, which are examined using normal light, DIF tissue samples are examined using fluorescent light. This makes it easier for pathologists to see exactly where in the tissue sample the proteins …
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Direct immunofluorescence

Direct immunofluorescence (DIF) is a specialized laboratory test pathologists use to identify specific proteins within a tissue sample. This test involves using antibodies attached to a fluorescent dye that glows brightly under a special microscope. By lighting up these proteins, DIF helps pathologists see their location and pattern within the tissue. Why is direct immunofluorescence …
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Desmoid tumour

Background: Desmoid tumour or deep fibromatosis is a benign (non-cancerous) tumour that starts in connective tissue. It is considered locally aggressive because it can grow into surrounding tissues and organs. The tumour can also grow back if not completely removed. However, it will not metastasize (spread) to other body parts. Symptoms of desmoid tumour The …
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Plasmacytoma

A plasmacytoma is a tumour made up of specialized immune cells called plasma cells. When a plasmacytoma forms outside of a bone it is called an extraosseous plasmacytoma. If only a single tumour is found in a bone without evidence of abnormal plasma cells in other parts of the body, it is called a solitary …
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Pheochromocytoma of the adrenal gland scaled score (PASS)

What is the Pheochromocytoma of the Adrenal Gland Scaled Score (PASS)? Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) is a tool that doctors use to predict the behaviour of a pheochromocytoma. A score of 3 or less means that the tumour is likely to behave in a non-cancerous manner and is cured by surgery …
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PASS score

What is the PASS score? The PASS (Pheochromocytoma of the Adrenal gland Scaled Score) is a tool that doctors use to predict the behaviour of a tumour called pheochromocytoma. A score of 3 or less means that the tumour is likely to behave in a non-cancerous manner and is cured by surgery alone. In contrast, …
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Salivary duct carcinoma

Salivary duct carcinoma is a cancer that starts in the salivary glands. The salivary glands are small organs that produce saliva to help chew, swallow, and digest food. This cancer is considered rare and tends to grow more aggressively than other types of salivary gland cancers. Salivary duct carcinoma commonly affects the parotid gland, the …
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Xanthoma

A xanthoma is a type of growth that forms under the skin or in other tissues of the body. It is made up of fat-filled cells called foamy histiocytes, which are a type of immune cell that has absorbed fat. Xanthomas can appear anywhere on the body but are most commonly found on the skin. …
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